反应详情

温度

85 °C

300 g of 3-nitrophenol are added to 800 ml of DMF. Then 240 g of sodium carbonate are added portionwise. Subsequently 270 g of chloroacetic acid methylester is added at 22° C. Then the mixture is stirred at 85° C. for six hours. After being cooled down to 25° C. it is given to 3 kg of water and 1 kg of ice. The resulting suspension is filtered off. The filter cake is washed with 300 g of water and dried in vacuum. Yield: 407 g.

1. temperatureAfter being cooled down to 25° C. it
2. filtrationThe resulting suspension is filtered off
3. washThe filter cake is washed with 300 g of water
4. customdried in vacuum