Piperidine → HCID 135510739, compound

HRID 414955Notes

Reaction equation

HRID 414955 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][C:6]1[NH:7][C:8](=[O:16])[C:9]([C:14]#[N:15])=[C:10](SC)[N:11]=1.[NH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][C:6]1[NH:7][C:8](=[O:16])[C:9]([C:14]#[N:15])=[C:10]([N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[N:11]=1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 58407838HCID 58407838, compound

Product 1

HCID 135510739HCID 135510739, compound

Procedure

100 mg (0.34 mmol) of 2-(3,4-dichlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are stirred with 261 mg (3.07 mmol) of piperidine at 85° C. for 16 h. After removal of the volatile constituents in vacuo, the residue is purified by preparative HPLC. 42 mg (38% of theory) of the title compound are obtained.

Workup

  1. customAfter removal of the volatile constituents in vacuo
  2. customthe residue is purified by preparative HPLC

Sources & evidence

ORD record
ord-17816114ba774dbab023c742b6a0f60a
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

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