Piperidine → HCID 135995035, compound

HRID 414956Notes

Reaction equation

HRID 414956 reaction equation
[CH2:1]([C:8]1[NH:9][C:10](=[O:18])[C:11]([C:16]#[N:17])=[C:12](SC)[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C>[CH2:1]([C:8]1[NH:9][C:10](=[O:18])[C:11]([C:16]#[N:17])=[C:12]([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 14022927HCID 14022927, compound

Product 1

HCID 135995035HCID 135995035, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

43 mg (0.17 mmol) of 2-benzyl-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are suspended in 0.3 ml of acetonitrile and stirred with 42.7 mg (0.50 mmol) of piperidine at 85° C. for 16 h. The resulting crude product is then purified by preparative HPLC. 11 mg (22% of theory) of the title compound are obtained.

Workup

  1. customThe resulting crude product is then purified by preparative HPLC

Sources & evidence

ORD record
ord-efd4b121fc5140f99f2a0f85a51910ef
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

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