Pyrrolidine → HCID 135994995, compound

HRID 414972Notes

Reaction equation

HRID 414972 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][C:7]2[NH:8][C:9](=[O:17])[C:10]([C:15]#[N:16])=[C:11](SC)[N:12]=2)=[CH:4][CH:3]=1.[NH:20]1[CH2:24][CH2:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][C:7]2[NH:8][C:9](=[O:17])[C:10]([C:15]#[N:16])=[C:11]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 58407870HCID 58407870, compound

Product 1

HCID 135994995HCID 135994995, compound

Procedure

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(4-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 244 mg (3.43 mmol) of pyrrolidine to give 45 mg (42% of theory) of the title compound.

Sources & evidence

ORD record
ord-fa953536c22440fea0f2a800dead68fc
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

Loading…