Pyrrolidine → HCID 135995021, compound

HRID 414979Notes

Reaction equation

HRID 414979 reaction equation
CS[C:3]1[N:4]=[C:5]([CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)[NH:6][C:7](=[O:11])[C:8]=1[C:9]#[N:10].[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>>[O:11]=[C:7]1[NH:6][C:5]([CH2:12][C:13]2[CH:17]=[CH:16][S:15][CH:14]=2)=[N:4][C:3]([N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[C:8]1[C:9]#[N:10]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 584079424-(Methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile

Product 1

HCID 135995021HCID 135995021, compound

Procedure

In analogy to the preparation of Example 1, 100 mg (0.38 mmol) of 4-(methylsulphanyl)-6-oxo-2-(3-thienylmethyl)-1,6-dihydropyrimidine-5-carbonitrile are reacted with 270 mg (3.80 mmol) of pyrrolidine to give 64 mg (59% of theory) of the title compound.

Sources & evidence

ORD record
ord-d6268044e8ea4c3cb7fdebde7cef5587
Source dataset
uspto-grants-2012_01
Patent number
US08088769B2

Reaction notes

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