HRID41500

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID679

Dimethyl sulfoxide

C2H6OS

HCID1118

Sulfuric acid

H2O4S

HCID3776

Isopropanol

C3H8O

结构：CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1

HCID66646296

未命名化合物

PRODUCTS

生成物

结构：CNc1nc(-c2cccc(NC(=O)c3ccc(C(=O)O)c(C)c3)c2)c2cc(OC)c(OC)cc2n1.O=S(=O)(O)O

HCID68829027

未命名化合物

PROCEDURE

实验过程

Dimethyl sulfoxide (1 mL) and sulfuric acid (26 μL) were added to and dissolved in methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (103.92 mg) by heating. Then, 2-propanol (3 mL) was added to the mixture and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (112.12 mg).

WORKUP

后处理

temperatureby heating
filtrationThe solid was collected by filtration

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9562c7bde316418084d6cd4b98abf39e
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08530654B2
来源说明: uspto-grants-2013_09

反应 SMILES

CS(C)=O.[S:5](=[O:9])(=[O:8])([OH:7])[OH:6].CC(O)C.[CH3:14][C:15]1[CH:23]=[C:22]([C:24]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]3[C:42]4[C:37](=[CH:38][C:39]([O:45][CH3:46])=[C:40]([O:43][CH3:44])[CH:41]=4)[N:36]=[C:35]([NH:47][CH3:48])[N:34]=3)[CH:28]=2)=[O:25])[CH:21]=[CH:20][C:16]=1[C:17]([OH:19])=[O:18]>>[S:5]([OH:9])([OH:8])(=[O:7])=[O:6].[CH3:14][C:15]1[CH:23]=[C:22]([C:24]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([C:33]3[C:42]4[C:37](=[CH:38][C:39]([O:45][CH3:46])=[C:40]([O:43][CH3:44])[CH:41]=4)[N:36]=[C:35]([NH:47][CH3:48])[N:34]=3)[CH:28]=2)=[O:25])[CH:21]=[CH:20][C:16]=1[C:17]([OH:19])=[O:18]