反应详情

2-(2-Chloro-4-nitro-phenoxymethyl)-pyridine (2.4 g, 9.07 mmol) is suspended in MeOH (30 ml) and treated wet 5% Pt/C (Degussa type, Aldrich, 0.8 g). The flask is flushed with hydrogen gas from a balloon and the reaction mixture is stirred under hydrogen atmosphere until reaction is complete by TLC (ca 2 hours). The reaction mixture is filtered through a Celite plug and the solvent is removed under reduced pressure. The crude product is redissolved in DCM, dried (MgSO4) and concentrated to yield 1.7 g (7.23 mmol, 80%) of the desired product.

1. customThe flask is flushed with hydrogen gas from a balloon
2. customis complete by TLC (ca 2 hours)
3. filtrationThe reaction mixture is filtered through a Celite plug
4. customthe solvent is removed under reduced pressure
5. dissolutionThe crude product is redissolved in DCM
6. dry with materialdried (MgSO4)
7. concentrationconcentrated