反应详情

To the solution of methyl 2-(4-(bromomethyl)phenyl)-5-fluorobenzo[d]oxazole-7-carboxylate (350 mg, 0.96 mmol) in methanol (20 mL), methylamine (6 mL) was added, the mixture was stirred at room temperature for 1 hr, then heated to 30° C. for 30 min; the solvents were evaporated and the residue was purified by pre-HPLC to obtain methyl 5-fluoro-2-(4-((methylamino)methyl)phenyl)benzo[d]oxazole-7-carboxylate as a white solid (25 mg, yield 8%). LC-MS (ESI) m/z 315 [M+1]+.

1. temperatureheated to 30° C. for 30 min
2. customthe solvents were evaporated
3. customthe residue was purified by pre-HPLC