Piperazine → Methyl 2-(4-(piperazin-1-ylmethyl)phenyl)benzo[d]oxazole-7-carboxylate

HRID 415211Notes

Reaction equation

HRID 415211 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:5][CH:4]=1.[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1>CO>[N:22]1([CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[O:10][C:11]4[C:17]([C:18]([O:20][CH3:21])=[O:19])=[CH:16][CH:15]=[CH:14][C:12]=4[N:13]=3)=[CH:5][CH:4]=2)[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 66621208Methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-7-carboxylate

Product 1

HCID 66621147Methyl 2-(4-(piperazin-1-ylmethyl)phenyl)benzo[d]oxazole-7-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To the mixture of methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-7-carboxylate (250 mg, 0.72 mmol) in methanol (2 mL), was added piperazine (186 mg, 2.16 mmol), and the resulting mixture was stirred at room temperature for 17 hr, then the solvents were evaporated to give methyl 2-(4-(piperazin-1-ylmethyl)phenyl)benzo[d]oxazole-7-carboxylate LC-MS (ESI) m/z 352 [M+1]+.

Workup

  1. customthe solvents were evaporated

Sources & evidence

ORD record
ord-f717b214b804400aa85244bc9b290176
Source dataset
uspto-grants-2012_01
Patent number
US08088760B2

Reaction notes

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