Dimethylamine → HCID 66621037, compound

HRID 415240Notes

Reaction equation

Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O:20][CH3:21])=[O:19])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1.[CH3:22][NH:23][CH3:24]>C(O)C>[CH3:22][N:23]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O:20][CH3:21])=[O:19])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1)[CH3:24]

Participants

Conditions

Temperature: 30 °C

Procedure

Methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-4-carboxylate (100 mg, 0.29 mmol) and dimethylamine (26 mg, 0.58 mmol) were added into ethanol (30 ml) and the mixture was stirred at 30° C. for 12 h. The resulting mixture was evaporated under reduced pressure. 60 mg of methyl 2-(4-((dimethylamino)methyl)phenyl)benzo[d]oxazole-4-carboxylate solid was obtained, yield: 44.5%. LC-MS (ESI) m/z: 311 (M+1)+.

Workup

customThe resulting mixture was evaporated under reduced pressure

Sources & evidence

ORD record: ord-e63e199336d445339421ff1a1a716b7e
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088760B2

Reaction notes

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