HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Methylhydroxylamine → Methyl 2-(4-((methoxyamino)methyl)phenyl)benzo[d]oxazole-7-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Methylhydroxylamine | HCID 4113 | — |
| Reactant | Methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-7-carboxylate | HCID 66621208 | — |
| Product | Methyl 2-(4-((methoxyamino)methyl)phenyl)benzo[d]oxazole-7-carboxylate | HCID 86633091 | 65% |
Reaction Steps
Following the experimental procedure as described in Example 144 C, and replacing methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-4-carboxylate with methyl 2-(4-(bromomethyl)phenyl)benzo[d]oxazole-7-carboxylate and substituting dimethylamine with methoxyamine, methyl 2-(4-((methoxyamino)methyl)phenyl)benzo[d]oxazole-7-carboxylate (Yield: 65%. LC-MS (ESI) m/z: 313 (M+1)+) was made.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08088760B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-1de2ab52085e4334a5ded581255bd7d9 |
| Source note | uspto-grants-2012_01 |