反应详情

To a solution of piperidine-3-carboxylic acid (10.7 g, 83 mmol) in ethanol (40 mL) was added thionyl chloride (22.5 mL) at 0° C. dropwise, the reaction mixture was refluxed overnight. Then the mixture was evaporated at reduced pressure to give 3-(ethoxycarbonyl)piperidinium hydrochloride. (13 g, Y: 100%). LC-MS (ESI) (m/z): 158 (M+1)+.

1. temperaturethe reaction mixture was refluxed overnight
2. customThen the mixture was evaporated at reduced pressure