反应详情

温度

0 °C

KSCN (10.76 g, 110.7 mmol) and pyridine (3.9 mL, 49.2 mmol) was added to 6-amino-2-{[(1S)-1-(2-fluorophenyl)ethyl]thio}pyrimidin-4-ol (6.53 g, 24.6 mmol) in DMF (70 mL). The mixture was cooled to 0° C. and Br2 was added dropwise. After 3.5 h the reaction mixture was poured into water and the formed precipitate was collected by filtration. The solid was suspended in a mixture of DMF (75 mL) and water (15 mL) and heated to 120° C. for 8 h. The reaction mixture was poured into water and the solid was collected by filtration and dried in vacuo at 40° C. to give the title compound (6.42 g, 81% yield).

1. filtrationthe formed precipitate was collected by filtration
2. additionThe solid was suspended in a mixture of DMF (75 mL) and water (15 mL)
3. temperatureheated to 120° C. for 8 h
4. additionThe reaction mixture was poured into water
5. filtrationthe solid was collected by filtration
6. customdried in vacuo at 40° C.