Methanol → HCID 66622667, compound

HRID 415365Notes

Reaction equation

HRID 415365 reaction equation
[OH-:1].[K+].Cl[C:4]1[S:5][C:6]2[C:11]([NH:12][C@H:13]([CH2:16][C:17]([F:20])([CH3:19])[CH3:18])[CH2:14][OH:15])=[N:10][C:9]([S:21][C@H:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[F:30])[CH3:23])=[N:8][C:7]=2[N:31]=1.[CH3:32]O>[Na+].[Cl-]>[F:20][C:17]([CH3:19])([CH3:18])[CH2:16][C@@H:13]([NH:12][C:11]1[C:6]2[S:5][C:4]([O:1][CH3:32])=[N:31][C:7]=2[N:8]=[C:9]([S:21][C@H:22]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[F:30])[CH3:23])[N:10]=1)[CH2:14][OH:15]

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 66623149HCID 66623149, compound

Product 1

HCID 66622667HCID 66622667, compound

Reagents, catalysts & solvents 1

HCID 5234Sodium ChlorideSolvent

Conditions

Temperature
50 °C

Procedure

KOH (0.050 g, 0.89 mmol) was added to (2R)-2-[(2-chloro-5-{[(1S)-1-(2-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-fluoro-4-methylpentan-1-ol in MeOH (5 mL) and the mixture was heated to 50° C. After 3 h the mixture was diluted with NaCl (aq) and extracted with CHCl3, the organic phase was dried (MgSO4) and evaporated to give the title compound.

Workup

  1. extractionextracted with CHCl3
  2. dry with materialthe organic phase was dried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-de05804dae25495994baa622ab98eeb6
Source dataset
uspto-grants-2012_01
Patent number
US08088780B2

Reaction notes

Loading…