Methanol → HCID 66622524, compound

HRID 415366Notes

Reaction equation

HRID 415366 reaction equation
[OH-:1].[K+].Cl[C:4]1[S:5][C:6]2[C:11]([NH:12][C@H:13]([CH2:16][CH2:17][CH3:18])[CH2:14][OH:15])=[N:10][C:9]([S:19][C@H:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[F:28])[CH3:21])=[N:8][C:7]=2[N:29]=1.[CH3:30]O>[Na+].[Cl-]>[F:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[C@@H:20]([S:19][C:9]1[N:10]=[C:11]([NH:12][C@H:13]([CH2:16][CH2:17][CH3:18])[CH2:14][OH:15])[C:6]2[S:5][C:4]([O:1][CH3:30])=[N:29][C:7]=2[N:8]=1)[CH3:21]

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 66623105HCID 66623105, compound

Product 1

HCID 66622524HCID 66622524, compound

Reagents, catalysts & solvents 1

HCID 5234Sodium ChlorideSolvent

Conditions

Temperature
50 °C

Procedure

KOH (0.089 g, 1.58 mmol) was added to (2R)-2-[(2-chloro-5-{[(1S)-1-(2-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]pentan-1-ol in MeOH (10 mL) and the mixture was heated to 50° C. After 3 h the mixture was diluted with NaCl (aq) and extracted with CHCl3, the organic phase was dried (MgSO4) and evaporated to give the title compound.

Workup

  1. extractionextracted with CHCl3
  2. dry with materialthe organic phase was dried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-9c6ee0291784442c99ba9f11854dab9f
Source dataset
uspto-grants-2012_01
Patent number
US08088780B2

Reaction notes

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