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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415366Generated: October 28, 2026

Methanol → HCID 66622524, compound

https://huagongshe.com/reaction/415366

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 66623105HCID 66623105—
SolventSodium ChlorideHCID 5234—
ProductHCID 66622524HCID 66622524—

Reaction Conditions

Temperature50 °C

Reaction Steps

KOH (0.089 g, 1.58 mmol) was added to (2R)-2-[(2-chloro-5-{[(1S)-1-(2-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]pentan-1-ol in MeOH (10 mL) and the mixture was heated to 50° C. After 3 h the mixture was diluted with NaCl (aq) and extracted with CHCl3, the organic phase was dried (MgSO4) and evaporated to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088780B2
Source datasetuspto-grants-2012_01
ORD IDord-9c6ee0291784442c99ba9f11854dab9f
Source noteuspto-grants-2012_01