Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 66623105 | HCID 66623105 | — |
| Solvent | Sodium Chloride | HCID 5234 | — |
| Product | HCID 66622524 | HCID 66622524 | — |
Reaction Steps
KOH (0.089 g, 1.58 mmol) was added to (2R)-2-[(2-chloro-5-{[(1S)-1-(2-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]pentan-1-ol in MeOH (10 mL) and the mixture was heated to 50° C. After 3 h the mixture was diluted with NaCl (aq) and extracted with CHCl3, the organic phase was dried (MgSO4) and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088780B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-9c6ee0291784442c99ba9f11854dab9f |
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| Source note | uspto-grants-2012_01 |
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