Methanol → HCID 66623122, compound

HRID 415367Notes

Reaction equation

HRID 415367 reaction equation
[OH-:1].[K+].Cl[C:4]1[S:5][C:6]2[C:11]([NH:12][C@H:13]([CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:14][OH:15])=[N:10][C:9]([S:20][C@H:21]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=3)[CH3:22])=[N:8][C:7]=2[N:30]=1.[CH3:31]O>[Na+].[Cl-]>[F:29][C:25]1[CH:24]=[C:23]([C@@H:21]([S:20][C:9]2[N:10]=[C:11]([NH:12][C@H:13]([CH2:16][CH:17]([CH3:19])[CH3:18])[CH2:14][OH:15])[C:6]3[S:5][C:4]([O:1][CH3:31])=[N:30][C:7]=3[N:8]=2)[CH3:22])[CH:28]=[CH:27][CH:26]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14797Potassium HydroxideHCID 66622736HCID 66622736, compound

Product 1

HCID 66623122HCID 66623122, compound

Reagents, catalysts & solvents 1

HCID 5234Sodium ChlorideSolvent

Conditions

Temperature
50 °C

Procedure

KOH (0.063 g, 1.12 mmol) was added to (2R)-2-[(2-chloro-5-{[(1S)-1-(3-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol in MeOH (5 mL) and the mixture was heated to 50° C. After 4 h the mixture was diluted with NaCl (aq) and extracted with CHCl3, the organic phase was dried (MgSO4) and evaporated to give the title compound.

Workup

  1. extractionextracted with CHCl3
  2. dry with materialthe organic phase was dried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-2242175838274e68b276f2df0333e696
Source dataset
uspto-grants-2012_01
Patent number
US08088780B2

Reaction notes

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