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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415367Generated: October 29, 2026

Methanol → HCID 66623122, compound

https://huagongshe.com/reaction/415367

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantPotassium HydroxideHCID 14797—
ReactantHCID 66622736HCID 66622736—
SolventSodium ChlorideHCID 5234—
ProductHCID 66623122HCID 66623122—

Reaction Conditions

Temperature50 °C

Reaction Steps

KOH (0.063 g, 1.12 mmol) was added to (2R)-2-[(2-chloro-5-{[(1S)-1-(3-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol in MeOH (5 mL) and the mixture was heated to 50° C. After 4 h the mixture was diluted with NaCl (aq) and extracted with CHCl3, the organic phase was dried (MgSO4) and evaporated to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088780B2
Source datasetuspto-grants-2012_01
ORD IDord-2242175838274e68b276f2df0333e696
Source noteuspto-grants-2012_01