Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 66622736 | HCID 66622736 | — |
| Solvent | Sodium Chloride | HCID 5234 | — |
| Product | HCID 66623122 | HCID 66623122 | — |
Reaction Steps
KOH (0.063 g, 1.12 mmol) was added to (2R)-2-[(2-chloro-5-{[(1S)-1-(3-fluorophenyl)ethyl]thio}[1,3]thiazolo[4,5-d]pyrimidin-7-yl)amino]-4-methylpentan-1-ol in MeOH (5 mL) and the mixture was heated to 50° C. After 4 h the mixture was diluted with NaCl (aq) and extracted with CHCl3, the organic phase was dried (MgSO4) and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088780B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-2242175838274e68b276f2df0333e696 |
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| Source note | uspto-grants-2012_01 |
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