Hydrochloric Acid → HCID 67251283, compound

HRID 41541Notes

Reaction equation

HRID 41541 reaction equation
[ClH:1].[C:2]1([CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][C:15]3([CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[C:14]2=[O:31])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1>C(Cl)Cl>[ClH:1].[C:2]1([CH2:12][N:13]2[CH2:18][CH2:17][CH2:16][C:15]3([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[C:14]2=[O:31])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67251780HCID 67251780, compound

Product 1

HCID 67251283HCID 67251283, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

HCl (4M in dioxane, 5 ml) was added to a solution of tert-butyl 2-(naphthalen-1-ylmethyl)-1-oxo-2,9-diazaspiro[5.5]undecane-9-carboxylate (377 mg, 0.9 mmol) in CH2Cl2 (2 ml) and the mixture was stirred at rt for 18 h. The volatiles were evaporated to afford 270 mg (87%) of crude 2-(naphthalen-1-ylmethyl)-2,9-diazaspiro[5.5]undecan-1-one hydrochloride, which was used without further purification.

Workup

  1. customThe volatiles were evaporated

Sources & evidence

ORD record
ord-981859121b6b4eb0befb928f803bec31
Source dataset
uspto-grants-2013_09
Patent number
US08530648B2

Reaction notes

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