Hydrochloric Acid → (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

HRID 415422Notes

Reaction equation

HRID 415422 reaction equation
[Cl:1]C1C(N(C)S(C)(=O)=O)=NC([NH:18][C@H:19]([C:21]2[N:26]=[CH:25][C:24]([F:27])=[CH:23][N:22]=2)[CH3:20])=NC=1NC1C=C(OC(C)C)NN=1.Cl>C(Cl)Cl.O1CCOCC1>[ClH:1].[F:27][C:24]1[CH:23]=[N:22][C:21]([C@@H:19]([NH2:18])[CH3:20])=[N:26][CH:25]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178458664HCID 178458664, compound

Product 1

HCID 66624037(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (S)-tert-butyl-1-(5-fluoropyrimidin-2-yl)ethylcarbamate (Method 10, 0.21 g, 0.87 mmol) in DCM (5 ml) was added HCl (1.3 ml, 5.2 mmol) in dioxane. The reaction was stirred at room temperature for 3 hours. The solvent was removed give the title compound as white solid (quantitative). MS: Calcd.: 141. Found: [M+H]+ 142.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-d20ef68b58ab45469f440564dbe7d410
Source dataset
uspto-grants-2012_01
Patent number
US08088784B2

Reaction notes

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