Triethylamine → HCID 50993642, compound

HRID 415423Notes

Reaction equation

HRID 415423 reaction equation
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([NH2:7])[CH:3]=1.C(N(CC)CC)C.[Cl:15][C:16]1[N:21]=[C:20](Cl)[C:19]([F:23])=[CH:18][N:17]=1>CCO>[Cl:15][C:16]1[N:21]=[C:20]([NH:7][C:4]2[CH:3]=[C:2]([CH3:1])[NH:6][N:5]=2)[C:19]([F:23])=[CH:18][N:17]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 2507052,4-Dichloro-5-fluoropyrimidine

Product 1

HCID 50993642HCID 50993642, compoundYield 49.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 5-methyl-1H-pyrazol-3-amine (612 mg, 6.0 mmol) in absolute EtOH (10 ml) was added triethylamine (1.1 ml) and 2,4-dichloro-5-fluoropyrimidine (1.0 g, 6.0 mmol) and the resulting solution was aged at room temperature for 12 hours. The mixture was partitioned between EtOAc and water. The organic layer was washed with brine and dried. The solvents were removed under reduced pressure to give the title compound as a solid (679 mg). m/z: 228.

Workup

  1. customThe mixture was partitioned between EtOAc and water
  2. washThe organic layer was washed with brine
  3. customdried
  4. customThe solvents were removed under reduced pressure

Sources & evidence

ORD record
ord-8f028b22ecba4b96b96b2c4a7e51ac51
Source dataset
uspto-grants-2012_01
Patent number
US08088784B2

Reaction notes

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