Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| Reactant | HCID 178507941 | HCID 178507941 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178506347 | HCID 178506347 | — |
Reaction Steps
To a solution of 2,4,5-trichloropyrimidine (1.00 g, 5.45 mmol) in THF (10 ml) at room temperature was added 5-(2,2,2-trifluoroethoxy)-1H-pyrazol-3-amine (986 mg, 5.45 mmol) and triethylamine (606 mg, 6.0 mmol) and the reaction mixture was stirred at 40° C. overnight. The suspension was filtered and washed with water and dried to give the desired product as a white solid. MS: 328 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088784B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-5e42d25a04144737b57c9dfec92140db |
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| Source note | uspto-grants-2012_01 |
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