Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415439Generated: October 28, 2026

Triethylamine → HCID 178506347, compound

https://huagongshe.com/reaction/415439

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylamineHCID 8471—
Reactant2,4,5-TrichloropyrimidineHCID 237259—
ReactantHCID 178507941HCID 178507941—
SolventTetrahydrofuranHCID 8028—
ProductHCID 178506347HCID 178506347—

Reaction Conditions

Temperature40 °C

Reaction Steps

To a solution of 2,4,5-trichloropyrimidine (1.00 g, 5.45 mmol) in THF (10 ml) at room temperature was added 5-(2,2,2-trifluoroethoxy)-1H-pyrazol-3-amine (986 mg, 5.45 mmol) and triethylamine (606 mg, 6.0 mmol) and the reaction mixture was stirred at 40° C. overnight. The suspension was filtered and washed with water and dried to give the desired product as a white solid. MS: 328 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08088784B2
Source datasetuspto-grants-2012_01
ORD IDord-5e42d25a04144737b57c9dfec92140db
Source noteuspto-grants-2012_01