Triethylamine → HCID 178506347, compound

HRID 415439Notes

Reaction equation

HRID 415439 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([Cl:9])=[CH:4][N:3]=1.[F:10][C:11]([F:21])([F:20])[CH2:12][O:13][C:14]1[NH:18][N:17]=[C:16]([NH2:19])[CH:15]=1.C(N(CC)CC)C>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([NH:19][C:16]2[CH:15]=[C:14]([O:13][CH2:12][C:11]([F:20])([F:10])[F:21])[NH:18][N:17]=2)[C:5]([Cl:9])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2372592,4,5-TrichloropyrimidineHCID 178507941HCID 178507941, compound

Product 1

HCID 178506347HCID 178506347, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

To a solution of 2,4,5-trichloropyrimidine (1.00 g, 5.45 mmol) in THF (10 ml) at room temperature was added 5-(2,2,2-trifluoroethoxy)-1H-pyrazol-3-amine (986 mg, 5.45 mmol) and triethylamine (606 mg, 6.0 mmol) and the reaction mixture was stirred at 40° C. overnight. The suspension was filtered and washed with water and dried to give the desired product as a white solid. MS: 328 (M+1).

Workup

  1. filtrationThe suspension was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-5e42d25a04144737b57c9dfec92140db
Source dataset
uspto-grants-2012_01
Patent number
US08088784B2

Reaction notes

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