Hydrochloric Acid → (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

Participants

Reaction Steps

To a solution of N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-(2R)-methylpropane-2-sulfinamide (Method 52, 655 mg, 2.67 mmol) in dry dioxane (20 ml) was added HCl (3.4 ml, 13.3 mmol) in dioxane. The reaction was stirred at room temperature for 3 hours. The solvent was removed to give the title compound as white solid (quantitative). MS: Calcd.: 141. Found: [M+H]+142.

Provenance & Evidence