Hydrochloric Acid → (S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

HRID 415448Notes

Reaction equation

HRID 415448 reaction equation
[F:1][C:2]1[CH:3]=[N:4][C:5]([C@@H:8]([NH:10]S([C@H](C)CC)=O)[CH3:9])=[N:6][CH:7]=1.[ClH:17]>O1CCOCC1>[ClH:17].[F:1][C:2]1[CH:3]=[N:4][C:5]([C@@H:8]([NH2:10])[CH3:9])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66623763HCID 66623763, compound

Product 1

HCID 66624037(S)-1-(5-Fluoropyrimidin-2-yl)ethanamine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-(2R)-methylpropane-2-sulfinamide (Method 52, 655 mg, 2.67 mmol) in dry dioxane (20 ml) was added HCl (3.4 ml, 13.3 mmol) in dioxane. The reaction was stirred at room temperature for 3 hours. The solvent was removed to give the title compound as white solid (quantitative). MS: Calcd.: 141. Found: [M+H]+142.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-312c9f34351c4bc9aa650f8177c74dfa
Source dataset
uspto-grants-2012_01
Patent number
US08088784B2

Reaction notes

Loading…