Sulfuric acid magnesium salt (1:1) → HCID 86633720, compound

HRID 415468Notes

Reaction equation

HRID 415468 reaction equation
[Cl:1][C:2]1[C:11]([N+:12]([O-])=O)=[C:10]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.S([O-])([O-])(=O)=O.[Mg+2]>>[Cl:1][C:2]1[C:11]([NH2:12])=[C:10]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 86633719HCID 86633719, compound

Product 1

HCID 86633720HCID 86633720, compoundYield 85.7%

Procedure

The method of Part B of Example 1 was used to hydrogenate 2-chloro-3-nitro-N-(tetrahydro-2H-pyran-4-ylmethyl)quinolin-4-amine (7 g, 20 mmol) with the modifications that the reaction was stopped after four hours, and magnesium sulfate was added to the mixture before filtration. 2-Chloro-N4-(tetrahydro-2H-pyran-4-ylmethyl)quinoline-3,4-diamine (5 g) was isolated as a sticky, amber solid.

Sources & evidence

ORD record
ord-713ba68f5e8f4b719bfb37a03f0424c0
Source dataset
uspto-grants-2012_01
Patent number
US08088790B2

Reaction notes

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