反应详情

A solution of 4-chloroquinolin-3-amine (3.70 g, 20.74 mmol) and 4-bromobutyryl chloride (11.54 g, 62.22 mmol) dissolved in 100 mL of 1,2-dichloroethane was heated to reflux. After 17 hours the reaction was cooled to room temperature, diluted with dichloromethane, washed with saturated aqueous K2CO3, H2O and brine, dried over Na2SO4, and concentrated under reduced pressure to give a brown solid. The solid was triturated with a mixture of hexane and ether, filtered and dried to give 4-bromo-N-(4-chloroquinolin-3-yl)butanamide (3.65 g) as a brown solid.

1. temperaturewas heated to reflux
2. washwashed with saturated aqueous K2CO3, H2O and brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated under reduced pressure
5. customto give a brown solid
6. customThe solid was triturated with a mixture of hexane and ether
7. filtrationfiltered
8. customdried