反应详情

温度

82 °C

A mixture of 4-bromo-N-(4-chloroquinolin-3-yl)butanamide (2.090 g, 6.379 mmol) and O-benzylhydroxylamine hydrochloride (1.527 g, 9.569 mmol) in 20 mL of isopropanol was heated to 82° C. under an atmosphere of N2. After 18 hours the solution was cooled, solids were filtered off and rinsed with ether. The brown solid was dried to give 1.87 g of 2-(3-chloropropyl)-1H-imidazo[4,5-c]quinolin-1-ol.

1. temperatureAfter 18 hours the solution was cooled
2. filtrationsolids were filtered off
3. washrinsed with ether
4. customThe brown solid was dried