反应详情

3-[(2-Chloro-3-nitroquinolin-4-yl)amino]propan-1-ol 11.53 g), acetonitrile (110 mL), and 5% platinum on carbon (1.3 g) were added sequentially to a Parr vessel. The vessel was placed under hydrogen pressure, 40 psi (2.8×105 Pa) for 4 hours. The reaction mixture was filtered through a layer of CELITE filter aid and the filtrate was concentrated under reduced pressure. The residue was dried under vacuum for 2 hours to provide 9.97 g of 3-[(3-amino-2-chloroquinolin-4-yl)amino]propan-1-ol as a brown sticky oil.

1. customfor 4 hours
2. filtrationThe reaction mixture was filtered through a layer of CELITE
3. filtrationfilter aid
4. concentrationthe filtrate was concentrated under reduced pressure
5. customThe residue was dried under vacuum for 2 hours