反应详情

A mixture of 3-[(6-bromohexyl)oxy]benzenecarboxamide (2.10 g, 7 mmol, 1 equiv.) and triphenylphosphine (1.93 g, 7.35 mmol, 1.05 equiv.) in CH3CN (30 ml) was heated under reflux for 72 h. The solvent was evaporated under reduced pressure and the residue was triturated with dry Et2O until it solidified. The solid was filtered and dried in vacuo to give the desired compound as a white solid (4.0 g, 100%). HPLC-MS (method 1): m/z 482 [M−Br]+, Rt=3.65 min.

1. temperaturewas heated
2. temperatureunder reflux for 72 h
3. customThe solvent was evaporated under reduced pressure
4. customthe residue was triturated with dry Et2O until it
5. filtrationThe solid was filtered
6. customdried in vacuo