5-Bromo-2-(bromomethyl)-1,3-benzothiazole → 3-(5-Bromo-benzothiazol-2-ylmethoxy)-2,6-difluoro-benzamide

HRID 415624Notes

Reaction equation

HRID 415624 reaction equation
[F:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[C:10]([NH2:12])=[O:11].[Br:13][C:14]1[CH:15]=[CH:16][C:17]2[S:21][C:20]([CH2:22]Br)=[N:19][C:18]=2[CH:24]=1>>[Br:13][C:14]1[CH:15]=[CH:16][C:17]2[S:21][C:20]([CH2:22][O:8][C:7]3[C:2]([F:1])=[C:3]([C:10]([NH2:12])=[O:11])[C:4]([F:9])=[CH:5][CH:6]=3)=[N:19][C:18]=2[CH:24]=1

Participants

3

Reactant 2

HCID 144586425-Bromo-2-(bromomethyl)-1,3-benzothiazoleHCID 451201362,6-Difluoro-3-hydroxybenzamide

Product 1

HCID 462370143-(5-Bromo-benzothiazol-2-ylmethoxy)-2,6-difluoro-benzamideYield 81%

Procedure

Synthesised from 2,6-difluoro-3-hydroxybenzenecarboxamide and 5-bromo-2-(bromomethyl)-1,3-benzothiazole, according to Method B, scheme 2. Yield 81%, mp 244-246° C., HPLC-MS (method 1): m/z 399, 401 [M+H]+, Rt=3.98 min.

Sources & evidence

ORD record
ord-fb2c0cf19dc74dcbbe4151f8976649d8
Source dataset
uspto-grants-2012_01
Patent number
US08088791B2

Reaction notes

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