HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 415703Generated: October 27, 2026
Dimethylformamide → 4-(2-nitro-4,5-dimethylphenoxymethyl)-3-methylbenzoic Acid Methyl Ester
https://huagongshe.com/reaction/415703
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4,5-Dimethyl-2-nitrophenol | HCID 349117 | — |
| Reactant | Methyl 3-methyl-4-(((methylsulfonyl)oxy)methyl)benzoate | HCID 86591975 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-nitro-4,5-dimethylphenoxymethyl)-3-methylbenzoic Acid Methyl Ester | HCID 58891908 | 91.6% |
Reaction Steps
Under atmosphere of argon, a mixture of 2-nitro-4,5-dimethylphenol (4 g), DMF (100 ml), potassium carbonate (6.6 g) and 4-mesyloxymethyl-3-methylbenzoic acid methyl ester (6.8 g) were stirred for 15 minutes at 60° C. After the termination of reaction, the mixture was cooled and poured into iced water. The mixture was extracted with ethyl acetate-hexane. The organic layer was washed, dried, concentrated under reduced pressure to give the title compound (7.22 g) having the following physical data.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08088802B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-84813aec54484b8b84aca97fe3f1c303 |
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| Source note | uspto-grants-2012_01 |
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