反应详情

温度

60 °C

Under atmosphere of argon, a mixture of 2-nitro-4,5-dimethylphenol (4 g), DMF (100 ml), potassium carbonate (6.6 g) and 4-mesyloxymethyl-3-methylbenzoic acid methyl ester (6.8 g) were stirred for 15 minutes at 60° C. After the termination of reaction, the mixture was cooled and poured into iced water. The mixture was extracted with ethyl acetate-hexane. The organic layer was washed, dried, concentrated under reduced pressure to give the title compound (7.22 g) having the following physical data.

1. customAfter the termination of reaction
2. temperaturethe mixture was cooled
3. extractionThe mixture was extracted with ethyl acetate-hexane
4. washThe organic layer was washed
5. customdried
6. concentrationconcentrated under reduced pressure