反应详情

Methyl acrylic acid (510 mg, 6 mmol) in DMA (10 ml) was treated with thionyl chloride (714 mg, 6 mmol) at 0° C. The mixture was stirred for 30 min then 4-cyano-3-trifluoromethyl-aniline (1.0 g, 6.0 mmol) was added. The resulting suspension was stirred overnight and then quenched with NaHCO3. The reaction mixture was extracted with ethyl acetate, washed with brine and dried with Na2SO4. The resulting concentrated crude product was purified on column (Ethyl acetate:Hexane, 1:2) to yield the title compound as a yellow solid.

1. stirringThe resulting suspension was stirred overnight
2. customquenched with NaHCO3
3. extractionThe reaction mixture was extracted with ethyl acetate
4. washwashed with brine
5. dry with materialdried with Na2SO4
6. concentrationThe resulting concentrated crude product
7. customwas purified on column (Ethyl acetate:Hexane, 1:2)