反应详情

温度

80 °C

Treat a solution of trifluoro-methanesulfonic acid 3,5-dichloro-4-[(R)-2-oxo-1-(tetrahydro-pyran-4-yl)-pyrrolidin-3-ylmethyl]-phenyl ester (3.0 g, 6.3 mmol), 4-methoxycarbonylphenylboronic acid (2.3 g, 13 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.73 g, 0.63 mmol) in dimethoxyethane (40 mL) with 2M aqueous potassium carbonate (9.5 mL). Heat the mixture to 80° C. overnight. Cool to room temperature, quench with 1N hydrochloric acid and extract with ethyl acetate. Wash the organic layer with brine, dry over magnesium sulfate, and filter. Purify the crude material by silica gel chromatography using hexanes:ethyl acetate to afford 2.56 g (88%) of desired product: MS (m/z): 462 (M+).

1. temperatureCool to room temperature
2. customquench with 1N hydrochloric acid
3. extractionextract with ethyl acetate
4. washWash the organic layer with brine
5. dry with materialdry over magnesium sulfate
6. filtrationfilter
7. customPurify the crude material by silica gel chromatography