1-Methylpiperazine → HCID 66621548, compound

Participants

Reaction Steps

Alternative procedure to prepare Example 46: Using the procedure to synthesize Preparation 76 and using reagents 3′,5′-dichloro-4′-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid (350 mg, 0.78 mmol) and N-methyl piperazine (157 mg, 1.6 mmol) affords 103 mg (23%) of the title compound: Mass spectrum (apci) m/z=528.2 (M+H−HCl).

Provenance & Evidence