1-Methylpiperazine → HCID 66621548, compound

HRID 416008Notes

Reaction equation

HRID 416008 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:22]2[CH:27]=[CH:26][C:25]([C:28]([OH:30])=O)=[CH:24][CH:23]=2)[CH:5]=[C:6]([Cl:21])[C:7]=1[CH2:8][CH:9]1[CH2:13][CH2:12][N:11]([CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:10]1=[O:20].[CH3:31][N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[ClH:1].[CH:14]1([N:11]2[CH2:12][CH2:13][CH:9]([CH2:8][C:7]3[C:2]([Cl:1])=[CH:3][C:4]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([N:35]5[CH2:36][CH2:37][N:32]([CH3:31])[CH2:33][CH2:34]5)=[O:30])=[CH:24][CH:23]=4)=[CH:5][C:6]=3[Cl:21])[C:10]2=[O:20])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 59299497HCID 59299497, compound

Product 1

HCID 66621548HCID 66621548, compoundYield 46.7%

Procedure

Alternative procedure to prepare Example 46: Using the procedure to synthesize Preparation 76 and using reagents 3′,5′-dichloro-4′-(1-cyclohexyl-2-oxo-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid (350 mg, 0.78 mmol) and N-methyl piperazine (157 mg, 1.6 mmol) affords 103 mg (23%) of the title compound: Mass spectrum (apci) m/z=528.2 (M+H−HCl).

Workup

  1. customAlternative procedure to prepare Example 46
  2. customto synthesize
  3. customPreparation 76

Sources & evidence

ORD record
ord-ac15dfce303546eaa7aa4636a62eb5e0
Source dataset
uspto-grants-2012_01
Patent number
US08088776B2

Reaction notes

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