Hexamethylenetetramine → 3,5-Dimethyl-4-hydroxybenzaldehyde

HRID 416033Notes

Reaction equation

HRID 416033 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[OH:9].C1N2CN3CN(C2)CN1C3.[C:20](O)(=[O:22])C.O>>[OH:9][C:3]1[C:4]([CH3:8])=[CH:5][C:6]([CH:20]=[O:22])=[CH:7][C:2]=1[CH3:1]

Participants

4

Reactant 3

HCID 4101HexamethylenetetramineHCID 113352,6-DimethylphenolHCID 21899381Acetic acid--water (1/1)

Product 1

HCID 752223,5-Dimethyl-4-hydroxybenzaldehyde

Conditions

Temperature
100 °C

Procedure

2,6-Dimethylphenol (0.34 g/mL) and hexamethylenetetramine (2 eq.) are dissolved in 2:1 acetic acid/water mixture. The whole is heated at 100° C. for 4 hours. The reaction mixture is cooled to room temperature and poured into a water/ice mixture. The precipitate is drained.

Workup

  1. temperatureThe reaction mixture is cooled to room temperature

Sources & evidence

ORD record
ord-300642b878b346b08d52c741b67963bd
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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