2,3-Dichloro-4-hydroxybenzaldehyde → 3-(2,3-Dichloro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethoxy)phenyl)thien-2-yl)prop-2-en-1-one

HRID 416049Notes

Reaction equation

HRID 416049 reaction equation
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:14][C:13]([C:15](=[O:17])[CH3:16])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[Cl:20][C:21]1[C:28]([Cl:29])=[C:27]([OH:30])[CH:26]=[CH:25][C:22]=1[CH:23]=O>>[Cl:20][C:21]1[C:28]([Cl:29])=[C:27]([OH:30])[CH:26]=[CH:25][C:22]=1[CH:23]=[CH:16][C:15]([C:13]1[S:14][C:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:1])([F:18])[F:19])=[CH:9][CH:8]=2)=[CH:11][CH:12]=1)=[O:17]

Participants

3

Reactant 2

HCID 5283802,3-Dichloro-4-hydroxybenzaldehydeHCID 591803511-(5-(4-(Trifluoromethoxy)phenyl)thien-2-yl)ethanone

Product 1

HCID 666239143-(2,3-Dichloro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethoxy)phenyl)thien-2-yl)prop-2-en-1-one

Procedure

3-(2,3-Dichloro-4-hydroxyphenyl)-1-(5-(4-(trifluoromethoxy)phenyl)thien-2-yl)prop-2-en-1-one is prepared from 1-(5-(4-(trifluoromethoxy)phenyl)thien-2-yl)-ethanone and 2,3-dichloro-4-hydroxybenzaldehyde according to general procedure B. The evaporation residue is crystallized from acetonitrile.

Workup

  1. customThe evaporation residue is crystallized from acetonitrile

Sources & evidence

ORD record
ord-9f175dfda4aa4822bbc3e6eeb6b28b3b
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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