4-Hydroxy-3-methylbenzaldehyde → 3-(4-Hydroxy-3-methylphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one

HRID 416056Notes

Reaction equation

HRID 416056 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([C:14](=[O:16])[CH3:15])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[OH:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=O)=[CH:22][C:21]=1[CH3:28]>>[OH:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=[CH:15][C:14]([C:12]2[S:13][C:9]([C:6]3[CH:5]=[CH:4][C:3]([C:2]([F:17])([F:1])[F:18])=[CH:8][CH:7]=3)=[CH:10][CH:11]=2)=[O:16])=[CH:22][C:21]=1[CH3:28]

Participants

3

Reactant 2

HCID 1399014-Hydroxy-3-methylbenzaldehydeHCID 41914941-(5-(4-(Trifluoromethyl)phenyl)thiophen-2-yl)ethan-1-one

Product 1

HCID 666240253-(4-Hydroxy-3-methylphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one

Procedure

3-(4-Hydroxy-3-methylphenyl)-1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one is prepared from 1-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)ethanone and 4-hydroxy-3-methylbenzaldehyde according to general procedure B. The evaporation residue is washed with dichloromethane.

Workup

  1. washThe evaporation residue is washed with dichloromethane

Sources & evidence

ORD record
ord-cac442d986954a10b0d48e9d6f6b45cd
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

Loading…