2,3-Dichloro-4-hydroxybenzaldehyde → 3-(2,3-Dichloro-4-hydroxyphenyl)-1-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one

HRID 416058Notes

Reaction equation

HRID 416058 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([C:9]2[S:13][C:12]([C:14](=[O:16])[CH3:15])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.[Cl:19][C:20]1[C:27]([Cl:28])=[C:26]([OH:29])[CH:25]=[CH:24][C:21]=1[CH:22]=O>>[Cl:19][C:20]1[C:27]([Cl:28])=[C:26]([OH:29])[CH:25]=[CH:24][C:21]=1[CH:22]=[CH:15][C:14]([C:12]1[S:13][C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:17])([F:1])[F:18])[CH:4]=2)=[CH:10][CH:11]=1)=[O:16]

Participants

3

Reactant 2

HCID 5283802,3-Dichloro-4-hydroxybenzaldehydeHCID 41914931-[5-[3-(Trifluoromethyl)phenyl]-2-thienyl]ethanone

Product 1

HCID 666243933-(2,3-Dichloro-4-hydroxyphenyl)-1-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one

Procedure

3-(2,3-Dichloro-4-hydroxyphenyl)-1-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)prop-2-en-1-one is prepared from 1-(5-(3-(trifluoromethyl)phenyl)thien-2-yl)ethanone and 2,3-dichloro-4-hydroxybenzaldehyde according to general procedure B, at 50° C. for 30 hours. The evaporation residue is purified by silica-gel chromatography.

Workup

  1. customThe evaporation residue is purified by silica-gel chromatography

Sources & evidence

ORD record
ord-b9e571a65dff4819a582bcc515451889
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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