HRID416061

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24758

Sodium hydride

HNa

HCID954258

4-Iodobenzyl bromide

C7H6BrI

结构：CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CCC(O)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl

HCID25062865

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)C(C)(C)Oc1ccc(CCC(OCc2ccc(I)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)s2)c(Cl)c1Cl

HCID25062867

未命名化合物

PROCEDURE

实验过程

Tert-butyl 2-(4-(3-(4-iodobenzyloxy)-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,3-dichlorophenoxy)-2-methylpropanoate is prepared from tert-butyl 2-(2,3-dichloro-4-(3-hydroxy-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate using 1.1 equivalents of sodium hydride and 1.1 equivalents of 4-iodobenzyl bromide according to general procedure H.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8c65d6f7a55b463b87fa5e56217b0ff8
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08088819B2
来源说明: uspto-grants-2012_01

反应 SMILES

[Cl:1][C:2]1[C:18]([Cl:19])=[C:17]([CH2:20][CH2:21][CH:22]([OH:38])[C:23]2[S:24][C:25]([C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][CH:29]=3)=[CH:26][CH:27]=2)[CH:16]=[CH:15][C:3]=1[O:4][C:5]([CH3:14])([CH3:13])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[H-].[Na+].[I:41][C:42]1[CH:49]=[CH:48][C:45]([CH2:46]Br)=[CH:44][CH:43]=1>>[I:41][C:42]1[CH:49]=[CH:48][C:45]([CH2:46][O:38][CH:22]([C:23]2[S:24][C:25]([C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:35])([F:36])[F:37])=[CH:30][CH:29]=3)=[CH:26][CH:27]=2)[CH2:21][CH2:20][C:17]2[CH:16]=[CH:15][C:3]([O:4][C:5]([CH3:13])([CH3:14])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])=[C:2]([Cl:1])[C:18]=2[Cl:19])=[CH:44][CH:43]=1