Trifluoroacetic acid → 2-(2-Bromo-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)acetic acid

HRID 416085Notes

Reaction equation

[Br:1][C:2]1[CH:16]=[C:15]([CH2:17][CH2:18][C:19](=[O:35])[C:20]2[S:21][C:22]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=3)=[CH:23][CH:24]=2)[CH:14]=[CH:13][C:3]=1[O:4][CH2:5][C:6]([O:8]C(C)(C)C)=[O:7].FC(F)(F)C(O)=O>>[Br:1][C:2]1[CH:16]=[C:15]([CH2:17][CH2:18][C:19](=[O:35])[C:20]2[S:21][C:22]([C:25]3[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:29][CH:30]=3)=[CH:23][CH:24]=2)[CH:14]=[CH:13][C:3]=1[O:4][CH2:5][C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 25059984HCID 25059984, compound

Product 1

HCID 250599852-(2-Bromo-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)acetic acid

Procedure

2-(2-Bromo-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)acetic acid is prepared from tert-butyl 2-(2-bromo-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)acetate according to general procedure E using 17 equivalents of trifluoroacetic acid.

Sources & evidence

ORD record: ord-43b9deb7a0f5479887093a8d16414d69
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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