Trifluoroacetic acid → HCID 25061284, compound

HRID 416098Notes

Reaction equation

C([CH2:5][C:6]([O:11][C:12]1[C:17]([CH3:18])=[CH:16][C:15]([CH2:19][CH2:20][C:21](=[O:37])[C:22]2[S:23][C:24]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=3)=[CH:25][CH:26]=2)=[CH:14][C:13]=1[CH3:38])([CH3:10])[C:7]([O-:9])=[O:8])(C)(C)C.FC(F)(F)C(O)=O>>[CH3:38][C:13]1[CH:14]=[C:15]([CH2:19][CH2:20][C:21](=[O:37])[C:22]2[S:23][C:24]([C:27]3[CH:28]=[CH:29][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:31][CH:32]=3)=[CH:25][CH:26]=2)[CH:16]=[C:17]([CH3:18])[C:12]=1[O:11][C:6]([CH3:10])([CH3:5])[C:7]([OH:9])=[O:8]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86638757HCID 86638757, compound

Product 1

HCID 25061284HCID 25061284, compound

Procedure

2-(2,6-Dimethyl-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-phenoxy)-2-methylpropanoic acid is prepared from tert-butyl-(2,6-dimethyl-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoate according to general procedure E using 10 equivalents of trifluoroacetic acid.

Sources & evidence

ORD record: ord-e1181eb984cc451b8a8e8d9fa76e5c83
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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