Trifluoroacetic acid → HCID 25060773, compound

HRID 416103Notes

Reaction equation

[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([CH2:16][CH2:17][C:18]([C:20]2[S:21][C:22]([C:25]3[CH:30]=[CH:29][C:28]([S:31][CH3:32])=[CH:27][CH:26]=3)=[CH:23][CH:24]=2)=[O:19])[CH:12]=[CH:11][C:3]=1[O:4][C:5]([CH3:10])([CH3:9])[C:6]([O-:8])=[O:7].FC(F)(F)C(O)=O>>[Cl:1][C:2]1[C:14]([Cl:15])=[C:13]([CH2:16][CH2:17][C:18]([C:20]2[S:21][C:22]([C:25]3[CH:26]=[CH:27][C:28]([S:31][CH3:32])=[CH:29][CH:30]=3)=[CH:23][CH:24]=2)=[O:19])[CH:12]=[CH:11][C:3]=1[O:4][C:5]([CH3:10])([CH3:9])[C:6]([OH:8])=[O:7]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86638758HCID 86638758, compound

Product 1

HCID 25060773HCID 25060773, compound

Procedure

2-(2,3-Dichloro-4-(3-(5-(4-(methylthio)phenyl)thien-2-yl)-3-oxopropyl)-phenoxy)-2-methylpropanoic acid is prepared from 2-(2,3-dichloro-4-(3-(5-(4-(methylthio)phenyl)thien-2-yl)-3-oxopropyl)phenoxy)-2-methylpropanoate according to general procedure E using 10 equivalents of trifluoroacetic acid. After stirring for 18 hours at room temperature, the reaction mixture is washed with water and then the dichloromethane is removed by evaporation under reduced pressure. The evaporation residue is purified by silica-gel chromatography.

Workup

washthe reaction mixture is washed with water
customthe dichloromethane is removed by evaporation under reduced pressure
customThe evaporation residue is purified by silica-gel chromatography

Sources & evidence

ORD record: ord-9d1d345036844fbcbb94fafd73437b25
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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