Trifluoroacetic acid → HCID 59180299, compound

HRID 416106Notes

Reaction equation

HRID 416106 reaction equation
[CH3:1][C:2]([O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20](=[O:36])[C:21]2[S:22][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=3)=[CH:24][CH:25]=2)=[CH:14][C:13]=1[CH3:37])([CH3:10])[C:3]([O:5]C(C)(C)C)=[O:4].FC(F)(F)C(O)=O>>[CH3:10][C:2]([O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20](=[O:36])[C:21]2[S:22][C:23]([C:26]3[CH:27]=[CH:28][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:30][CH:31]=3)=[CH:24][CH:25]=2)=[CH:14][C:13]=1[CH3:37])([CH3:1])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59180352HCID 59180352, compound

Product 1

HCID 59180299HCID 59180299, compound

Procedure

2-Methyl-2-(2-methyl-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)-propyl)phenoxy)propanoic acid is prepared from tert-butyl 2-methyl-2-(2-methyl-4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)propanoate according to general procedure E using 10 equivalents of trifluoroacetic acid. After stirring for 25 hours at room temperature, the reaction mixture is washed with water and then the dichloromethane is removed by evaporation under reduced pressure. The evaporation residue is purified by silica-gel chromatography.

Workup

  1. washthe reaction mixture is washed with water
  2. customthe dichloromethane is removed by evaporation under reduced pressure
  3. customThe evaporation residue is purified by silica-gel chromatography

Sources & evidence

ORD record
ord-ffff47e6c0584799b4e22042e67b7f82
Source dataset
uspto-grants-2012_01
Patent number
US08088819B2

Reaction notes

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