Trifluoroacetic acid → HCID 25060243, compound

HRID 416109Notes

Reaction equation

[O:1]=[C:2]([C:22]1[S:23][C:24]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=2)=[CH:25][CH:26]=1)[CH2:3][CH2:4][C:5]1[CH:21]=[CH:20][C:8]([O:9][CH:10]([CH2:18][CH3:19])[C:11]([O:13]C(C)(C)C)=[O:12])=[CH:7][CH:6]=1.FC(F)(F)C(O)=O>>[O:1]=[C:2]([C:22]1[S:23][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:31][CH:32]=2)=[CH:25][CH:26]=1)[CH2:3][CH2:4][C:5]1[CH:21]=[CH:20][C:8]([O:9][CH:10]([CH2:18][CH3:19])[C:11]([OH:13])=[O:12])=[CH:7][CH:6]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59180353HCID 59180353, compound

Product 1

HCID 25060243HCID 25060243, compound

Procedure

2-(4-(3-Oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-butanoic acid is prepared from tert-butyl 2-(4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)butanoate according to general procedure E using 10 equivalents of trifluoroacetic acid.

Sources & evidence

ORD record: ord-b3dd8ec16eb34541957c15224e8edca3
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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