Trifluoroacetic acid → HCID 25060245, compound

HRID 416110Notes

Reaction equation

[CH3:1][C:2]([O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20](=[O:36])[C:21]2[S:22][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=3)=[CH:24][CH:25]=2)=[CH:14][CH:13]=1)([CH3:10])[C:3]([O:5]C(C)(C)C)=[O:4].FC(F)(F)C(O)=O>>[O:36]=[C:20]([C:21]1[S:22][C:23]([C:26]2[CH:27]=[CH:28][C:29]([C:32]([F:35])([F:33])[F:34])=[CH:30][CH:31]=2)=[CH:24][CH:25]=1)[CH2:19][CH2:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][C:2]([CH3:10])([CH3:1])[C:3]([OH:5])=[O:4])=[CH:13][CH:14]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59180294HCID 59180294, compound

Product 1

HCID 25060245HCID 25060245, compound

Procedure

2-(4-(3-Oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)-2-methylpropanoic acid is prepared from tert-butyl 2-methyl-2-(4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)propanoate according to general procedure E using 10 equivalents of trifluoroacetic acid.

Sources & evidence

ORD record: ord-30955687a29b4593aa7b17e0851319ae
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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