Trifluoroacetic acid → HCID 25060244, compound

HRID 416111Notes

Reaction equation

[O:1]=[C:2]([C:20]1[S:21][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)=[CH:23][CH:24]=1)[CH2:3][CH2:4][C:5]1[CH:19]=[CH:18][C:8]([O:9][CH2:10][C:11]([O:13]C(C)(C)C)=[O:12])=[CH:7][CH:6]=1.FC(F)(F)C(O)=O>>[O:1]=[C:2]([C:20]1[S:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:29][CH:30]=2)=[CH:23][CH:24]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:18][CH:19]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59180310HCID 59180310, compound

Product 1

HCID 25060244HCID 25060244, compound

Procedure

2-(4-(3-Oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)acetic acid is prepared from tert-butyl 2-(4-(3-oxo-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)phenoxy)acetate according to general procedure E using 10 equivalents of trifluoroacetic acid.

Sources & evidence

ORD record: ord-fd8f9a8519e44ed2b5aa5827d0372dd3
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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