Methyl iodide → HCID 59180356, compound

HRID 416114Notes

Reaction equation

[OH:1][CH:2]([C:20]1[S:21][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)=[CH:23][CH:24]=1)[CH2:3][CH2:4][C:5]1[CH:17]=[C:16]([CH3:18])[C:8]([O:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=[O:12])=[C:7]([CH3:19])[CH:6]=1.[H-].[Na+].I[CH3:38]>>[CH3:38][O:1][CH:2]([C:20]1[S:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:32])[F:33])=[CH:29][CH:30]=2)=[CH:23][CH:24]=1)[CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH3:19])[C:8]([O:9][C:10]([CH3:15])([CH3:14])[C:11]([OH:13])=[O:12])=[C:16]([CH3:18])[CH:17]=1

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 24758Sodium hydride

HCID 59180325HCID 59180325, compound

Product 1

HCID 59180356HCID 59180356, compound

Procedure

2-(4-(3-Methoxy-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,6-dimethylphenoxy)-2-methylpropanoic acid is prepared from 2-(4-(3-hydroxy-3-(5-(4-(trifluoromethyl)phenyl)thien-2-yl)propyl)-2,6-dimethylphenoxy)-2-methylpropanoic acid using 2.1 equivalents of sodium hydride and 2.1 equivalents of iodomethane according to general procedure H.

Sources & evidence

ORD record: ord-cdc923d74897447194d1491ba27dbaf4
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08088819B2

Reaction notes

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